The Division of Cardiovascular Medicine is the featured cover of this months "Journal American College Cardiology: Cardiovascular Interventions."
We are proud of our faculty who have published a State-of-the-Art paper entitled, “Vascular Inflammation and Repair.”
Transplatelet Leukocyte Migration
At the site of stent implantation after percutaneous coronary intervention, endothelial cells are denuded, and the subendothelial matrix is exposed to flowing blood. Platelets and fibrinogen immediately adhere to the surface of the injured vessel. A multistep cascade of platelet and leukocyte adhesion molecules direct leukocyte adhesion to the adherent platelets in a process termed “secondary capture.” Leukocyte capture and rolling are mediated by interaction between platelet P-selectin and leukocyte P-selectin glycoprotein ligand (PSGL)-1. Arrest and firm adhesion are mediated by platelet glycoprotein (GP) Ib-alpha and leukocyte Mac-1. Chemokines stimulate transmigration into the extraluminal tissue.
Click here to read the article on Vascular Inflammation and Repair
Max Wicha MD 
